Answer:
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Step-by-step explanation:
Dendritic cells (DC) are the professional antigen-presenting cells of the immune system. In their quiescent and mature form, the presentation of self-antigens by DC leads to tolerance; whereas, antigen presentation by mature DC, after stimulation by pathogen-associated molecular patterns, leads to the onset of antigen-specific immunity. DC has been found in many of the major organs in mammals (e.g. skin, heart, lungs, intestines, and spleen), while the brain has long been considered devoid of DC in the absence of neuroinflammation. Consequently, microglia, the resident immune cell of the brain, has been charged with many functional attributes commonly ascribed to DC.