Final answer:
In sexual reproduction, offspring with genetic variations not directly inherited from their parents result from mutations, which could be due to various factors such as DNA replication errors and environmental influences, as well as the processes of meiosis and random gamete union.
Step-by-step explanation:
In sexual reproduction, offspring receive a mix of genes from both parents, leading to genetic variation. At times, these offspring exhibit new genetic variations not directly inherited from the parents, known as mutations. These variations can occur due to errors in DNA replication, environmental factors, or during the processes of crossing-over and independent assortment in meiosis. Additionally, the random union of gametes during fertilization further contributes to the genetic uniqueness of each individual.