Answer:
Temperature, pressure, and moisture/humidity are all factors to consider.
Warm air has a lower density and rises/becomes buoyant.
The air is less dense at higher elevations above sea level. To bring the same amount of oxygen into the lungs when running at high altitudes, you'll need to take more deep breaths.
Humidity is less dense at higher temperatures and pressures. The weight of water molecules is less than that of nitrogen and oxygen molecules. To get more moisture into the same volume of air, some of the heavier nitrogen and oxygen must be displaced.
Step-by-step explanation: