Answer:
The correct answer is Spain and Portugal.
Step-by-step explanation:
In the second half of 15th Century, this two countries had the leading role in this process which was enabled by the open connection to the ocean. They were the first ones who started searching for the water route to India.
Expedition of Vasco De Gama and Christopher Columbus and later Magellan were the most famous ones, as under the crown and Spain and Portugal discovered route to India, new continent and sailed across the globe.