Answer:
C. American Indians became hardier and fought off Spanish rule.
Step-by-step explanation:
A. is not the correct answer. Spanish did not feel exhausted as they could easily replace the armies or continue after the break from the mission.
B. is not correct. Foreign parties did not raid the Spanish during their missions.
C. is the correct answer. While Spanish armies had the weapons and means of the fighting the natives did not, American Indians started to learn new techniques and became more skilled in the fight against the Spains and their rulership.
D. is not the right answer. Spain continued to support missions through its duration.