The correct answer to this open question is the following.
It seems that this is a true or false question. If this is the case, the correct answer is true.
It is true that regional boundaries separate places that are completely different from each other.
If we consider the term "boundary" as a physical or imaginary division that separates two regions, it is most common to identify physical boundaries that limit or divide geographical regions. That is the case of rivers, mountain chains, lakes, deserts, or oceans. One good example of these physical boundaries could by the Rio Grande, which serves as a natural division or frontier between México and the United States.