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Why did the Spanish explore the southeastern region of North America during the 1500s?

User Talguy
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Answer:

They are evaluating each other and acting on their evaluations, setting up networks of friend, foe, and in-between.

Hernando De Soto explored the southeast region of North America for Spain, searching for gold, a suitable site for a colony, and an overland route from Mexico to the Atlantic.

User Techarch
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