Question

Many chemotherapy drugs used to treat cancer work by modifying the mitotic spindle. Paclitaxel works by interfering with normal microtubule breakdown during cell division and Vinblastine works by binding tubulin, thereby inhibiting the assembly of microtubules. How and where specifically do you think these drugs would stop a cancer cell

Answer 1

by inhibiting the mitotic spindle plasticity

Explanation:

In eukaryotic cells, the mitotic spindle is the cytoskeletal structure by which sister chromatids are separated during cell division. Spindle microtubules are known to drive chromosome segregation, while tubulins are Microtubule-Associated Proteins (MAPs) that attach to microtubules in order to modulate their dynamics. Antimitotic drugs are nowadays widely used in chemotherapy to disrupt microtubule assembly and chromosome segregation, thereby producing mitotic arrest and cell death (apoptosis).