The correct answer to this open question is the following.
Discuss how the fact that Louise lives in Leadville, CO, and will be competing in Birmingham, AL might affect her 40K cycling competition.
We are talking about important factors such as the altitude of one place in comparison to the other. In this case, Louise lives in Colorado, one of the highest places in the United States. When Louise practices in that kind of altitude her performance is different as would be the case in a low altitude location as Birmingham, Alabama. The body responds in a different way to the physical exercise effort.
This would be one physiological change. That is why it is recommended that she could get to Birmingham, at least two weeks before the competition so she can adjust her preparation to a low altitude place.