Question

Biochemical signaling that is transduced via the protein tyrosine kinase signal transduction cascade is involved in regulating cell growth and differentiation. Identify one example from the scientific literature of an example of how either structural proteins or enzymes involved in this pathway can used as viable anticancer targets. Please include the reference that you use.

Answer 1

Tyrosine kinases are therapeutic targets for anticancer compounds

Step-by-step explanation:

Tyrosine kinases are a type of enzymes capable of activating signaling network pathways by protein phosphorylation, which is a posttranslational modification where one phosphate group is added to the protein and thereby activating it. In the last years, tyrosine kinases have been used as therapeutic anticancer agents. For example, it has been shown that c-MET proto-oncogene, a receptor tyrosine kinase involved in signaling pathways, is targeted by the PROteolysis TArgeting Chimera (PROTAC). PROTAC is a drug that acts as an enzyme capable of removing unwanted proteins bound to this receptor.