Final answer:
A synaptic cleft is the fluid-filled gap between a presynaptic and postsynaptic neuron where neurotransmitters bind to receptive segments, leading to the opening of ligand-gated ion channels and initiating graded, excitatory or inhibitory postsynaptic potentials.
Step-by-step explanation:
Between each presynaptic and postsynaptic neuron is a synaptic cleft that is the fluid-filled space between them. Each presynaptic neuron releases neurotransmitters that bind with receptors in the receptive segment of a postsynaptic neuron. The ligand-gated ion channels of the receptive segment open when these molecules bind. Specific ions then cross the membrane, initiating a graded potential in the postsynaptic neuron.
This local potential is a small voltage change in the membrane potential. Graded potentials that occur in postsynaptic neurons are specifically called postsynaptic potentials, which can be either excitatory or inhibitory, leading to hyperpolarization or depolarization of the membrane.