The state must not annul federal laws, if they disagree with them, and however much these laws may be wrong and contradictory. This reinforces the need for us to vote consciously and rationally on the politicians who will occupy federal positions, because their choices can have strong effects across the country and on all citizens.
As an example of this, I will quote the law that freed slaves after the civil war. Although this law has had a beneficial effect on society, if states could override federal laws, Confederate states would retain their slaves and the black population would not have the right to citizenship and freedom that founded this country, causing low and unfair quality of life. to thousands of Americans.