40.2k views
3 votes
Schilders disease is a progressive degeneration of the central nervous system that leads to death by age 2. The disease is caused by a simple autosomal recessive mutation. A couple loses its first two children to Schilders disease. If they decide to have a third child, what is the probability that it will have the disease

1 Answer

3 votes

Answer:

The probability will be 25% (1/4)

Explanation:

Schilder's syndrome is a degenerative and progressive lethal disease caused by the demyelination of nerve cells in the brain and spinal cord. Since it is a lethal recessive autosomal disease, both the father and the mother have a single copy of the mutant allele, thereby the probability of obtaining a lethal combination will be:

SN X SN >>

1/2 x 1/2 = 1/4 = 25%

where N and S are normal and lethal alleles, respectivelyvely

User Yshahak
by
8.5k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.

9.4m questions

12.2m answers

Categories