Final answer:
Creon perceives Antigone's defiance as deeply offensive, especially because she is a woman, as evidenced by his lines that metaphorically equate her with a viper and an ill-fated husband's shrew.
Step-by-step explanation:
The central idea in Part 2 of Antigone that indicates Creon finds Antigone's defiance particularly offensive because she is a woman is most effectively supported by his line: "Woman, who like a viper unperceived Didst harbor in my house and drain my blood". This line signifies Creon’s view of Antigone as a deceptive and harmful presence within his household, emphasizing his perception of betrayal and the gendered insult of her being a woman.
Another line that supports this idea is when Creon says, "Ill fares the husband mated with a shrew, And her embraces very soon wax cold", depicting his belief that disobedient women, like Antigone, are detrimental to the order and well-being of a man’s life.