Question

The coagulation factor that has a pivotal rule in coagulation cascade is?

Answer 1

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prothrombin

Activated thrombin leads to cleavage of fibrinogen into fibrin monomers that, upon polymerization, form a fibrin clot. Therefore, activation of prothrombin is crucial in physiological and pathophysiological coagulation.

Answer 2

Factor X

Step-by-step explanation:

Factor X plays a pivotal role in blood clotting at the point of convergence of the two coagulation pathways. Accordingly, several rare mutations in the factor X gene have been identified that give rise to bleeding tendencies of variable severity.