Final answer:
To find the total reaction to the drug over the time periods t=1 to t=12 and t=12 to t=24, we need to evaluate the definite integral of the rate of reaction function within these intervals. The total reaction from t=1 to t=12 is 2ln(12) + 2arctan(12^(1/2)) - 2. The total reaction from t=12 to t=24 is 2ln(24) + 2arctan(24^(1/2)) - 2ln(12) - 2arctan(12^(1/2)).
Step-by-step explanation:
To find the total reaction to the drug over the time periods t=1 to t=12 and t=12 to t=24, we need to find the definite integral of the rate of reaction function within these intervals.
a. From t=1 to t=12:
We integrate R'(t) from t=1 to t=12:
∫[2/t + 1 + 1/(sqrt(t) + 1)] dt
= 2ln|t| + t^(1/2) + 2arctan(t^(1/2)) evaluated from t=1 to t=12.
Substituting the upper and lower limits into the integral, we get:
2ln(12) + 12^(1/2) + 2arctan(12^(1/2)) - 2ln(1) - 1^(1/2) - 2arctan(1^(1/2))
= 2ln(12) + 12^(1/2) + 2arctan(12^(1/2)) - 2 - 2arctan(1)
= 2ln(12) + 2arctan(12^(1/2)) - 2
So, the total reaction to the drug from t=1 to t=12 is 2ln(12) + 2arctan(12^(1/2)) - 2.
b. From t=12 to t=24:
We follow the same steps as above, but substitute the upper and lower limits t=24 and t=12:
2ln(24) + 2arctan(24^(1/2)) - 2ln(12) - 2arctan(12^(1/2))
= 2ln(24) + 2arctan(24^(1/2)) - 2ln(12) - 2arctan(12^(1/2))
Therefore, the total reaction to the drug from t=12 to t=24 is 2ln(24) + 2arctan(24^(1/2)) - 2ln(12) - 2arctan(12^(1/2)).