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A doctor released the results of clinical trials for a vaccine to prevent a particular disease. In these clinical​ trials, 200,000 children were randomly divided in two groups. The subjects in group 1​ (the experimental​ group) were given the​ vaccine, while the subjects in group 2​ (the control​ group) were given a placebo. Of the 100,000 children in the experimental​ group, 21 developed the disease. Of the 100,000 children in the control​ group, 30 developed the disease.

a) Does it appear to be the case that the vaccine was effective? Use the α = 0.01 level of significance.
Identify the null and alternative hypotheses for this test.
c) Find the test statistic for this hypothesis test. (Round to two decimal places as needed.)

1 Answer

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Answer:

1) No, there is not enough evidence to support the claim that the vaccine was effective (P-value=0.104) .

The null and alternative hypothesis are:


H_0: \pi_1-\pi_2=0\\\\H_a:\pi_1-\pi_2< 0

being the subindex 1 for the experimental group and subindex 2 for the control group.

2) Test statistic z=-1.26

Explanation:

This is a hypothesis test for the difference between proportions.

The claim is that the vaccine was effective.

Then, the null and alternative hypothesis are:


H_0: \pi_1-\pi_2=0\\\\H_a:\pi_1-\pi_2< 0

The significance level is 0.01.

The sample 1 (experimental group), of size n1=100000 has a proportion of p1=0.0002.


p_1=X_1/n_1=21/100000=0.0002

The sample 2 (control group), of size n2=100000 has a proportion of p2=0.0003.


p_2=X_2/n_2=30/100000=0.0003

The difference between proportions is (p1-p2)=-0.0001.


p_d=p_1-p_2=0.0002-0.0003=-0.0001

The pooled proportion, needed to calculate the standard error, is:


p=(X_1+X_2)/(n_1+n_2)=(21+30)/(100000+100000)=(51)/(200000)=0.00026

The estimated standard error of the difference between means is computed using the formula:


s_(p1-p2)=\sqrt{(p(1-p))/(n_1)+(p(1-p))/(n_2)}=\sqrt{(0.00026*0.99974)/(100000)+(0.00026*0.99974)/(100000)}\\\\\\s_(p1-p2)=√(0+0.0000000025)=√(0.0000000051)=0.000071

Then, we can calculate the z-statistic as:


z=(p_d-(\pi_1-\pi_2))/(s_(p1-p2))=(-0.00009-0)/(0.000071)=(-0.00009)/(0.000071)=-1.26

This test is a left-tailed test, so the P-value for this test is calculated as (using a z-table):


P-value=P(z<-1.26)=0.104

As the P-value (0.104) is bigger than the significance level (0.01), the effect is not significant.

The null hypothesis failed to be rejected.

There is not enough evidence to support the claim that the vaccine was effective.

User Eduardo Quintana
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