Caution: I am not a 100% sure but would love to help you out as max as I can.
So since you have to choose two answer choices, you have to choose between answers A and D, and B and D.
I believe A is one answer because if a mutation occurs and the gene cannot work anymore, the body will know to delete itself because of how much damage it can cause. Additionally, I know B is the answer because duplicated genes contain many variations, and I believe a mutation would occur to have it occur even more but in the future. Duplications that do not have severe effects can persist over generations, allowing mutations to accumulate.