Question

Cancer cells have many alterations in their metabolic pathways, including some that alter the way they metabolize and use glucose. This is known as the Warburg effect. One component of the Warburg effect is the inhibition of the enzyme that converts pyruvate to acetyl CoA. Under these conditions, what metabolite will be elevated in cancer cells as compared to noncancerous cells even under normal oxygen saturation?Choose one:A. lactateB. pyruvateC. CO2D. NADH

Answer 1

A. lactate

Step-by-step explanation:

Warburg effect in oncology is defined as the alteration in metabolic pathway of cancer cells that allow glucose fermentation even in the presence of oxygen.

Normal cells or noncancerous cells undergo oxidative phosphorylation to produce energy. but cancer cell, produce their energy through a high rate of glycolysis which increases the metabolite lactate by lactic acid fermentation even in the presence of adequate oxygen.

Hence, the correct option is A.