Question

The phosphofructokinase (PFK) reaction is a major control point in glycolysis. It is the slowest reaction in glycolysis and is regulated by several molecules, but not by naturally changing concentrations of reactants and products. The molecules mentioned below allosterically regulate PFK activity. Indicate whether each condition described increases or reduces PFK activity (specifically in mammalian liver).

Answer 1

To keep cells alive, ATP production is necessary, the process by which it is produced is glycolysis, one of the most important enzymes in this process is phosphofructokinase (PFK) that performs the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.

allosteric proteins, such as hemoglobin, contain multisubunit proteins such as phosphofructokinase, which produce a chain reaction by stimulating their units.

In enzymes such as PFK, which contain allosteric particles, their functions can be modified by attaching an activator or inhibitor to their receptor, which when applied will produce a chain reaction of the other subunits, one will activate the next, and so on until it occurs. the desired reaction