Question

Which of the following might happen in individuals that had a nonsense mutation in the middle of the gene for growth hormone (GH) ?

a) Their anterior pituitary would secrete high levels of growth hormone (GH)
b) Their hypothalamus would secrete low levels of somatostatin
c) Their liver would secrete high levels of somatomedins
d) Their hypothalamus would secrete low levels growth hormone-releasing hormone (GH-RH)
e) They would grow larger than normal

Answer 1

d) Their hypothalamus would secrete low levels growth hormone-releasing hormone (GH-RH)

Step-by-step explanation:

A nonsense mutation is responsible for the substitution of amino acid with a stop codon. This premature stop codon causes reduction in required protein or product.

Growth hormone (GH) are produced by the pituitary gland in the braintaht os responsible for normal human growth and development. Gonadotropin-releasing hormone (GnRH) are gowth hormones that release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secreted from the hypothalamus.

Due, to nonsense mutation hypothalamus would secrete low levels growth hormone-releasing hormone (GH-RH).

Hence, the correct option is d.