Question

Pyruvate kinase catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP in the last step of glycolysis, forming pyruvate in the process. Vertebrates have several isozymes of pyruvate kinase, which can be allosterically inhibited by compounds including ATP and acetyl-CoA. What is an effect of cAMP-dependent protein kinase (PKA) inactivation of the liver isozyme but not the muscle isozyme

Answer 1

By inhibiting pyruvate kinase in the liver isoenzyme, the muscle will initiate the lactic acid fermentation process that will provide NAD to allow glycolysis