Question

Clostridium perfringens causes gas gangrene, a serious infection of the muscle tissues that can lead to amputation. Clostridium are Gram-positive endospore-formers and obligate anaerobes that are killed when exposed to oxygen. Which of the following virulence factors would be most helpful to this organism in establishing an infection?

In order to establish a successful infection, a pathogen must arrive at a susceptible site, adhere, invade, acquire nutrients, and grow.

Clostridium perfringens causes gas gangrene, a serious infection of the muscle tissues that can lead to amputation. Clostridium are Gram-positive endospore-formers and obligate anaerobes that are killed when exposed to oxygen. Which of the following virulence factors would be most helpful to this organism in establishing an infection?

A endotoxin
B nuclease, an enzyme that breaks down nucleic acids
C collagenase, an enzyme that destroys collagen, which is a major protein of connective tissues
D a neurotoxin

Answer 1

Which of the following virulence factors would be most helpful to this organism in establishing an infection? C collagenase, an enzyme that destroys collagen, which is a major protein of connective tissues

Step-by-step explanation:

Clostridium Perfringens produces the enzyme collagenase, that breaks down collagen, which is a major supportive protein of connective tissues, found in tendons, cartilage and bones. The pathogenesis of this bacteria is assisted by collagenase in destroying extracellular structures. This is a virulence factor which helps in spreading gas gangrene.