Final answer:
The Mona Lisa was painted by Leonardo da Vinci between 1503 and 1505, and is housed in the Musée du Louvre in Paris. Known for its enigmatic smile, it's a Renaissance icon and the most recognized painting globally.
Step-by-step explanation:
The Mona Lisa was painted by Leonardo da Vinci in the early 16th century, specifically around 1503 to 1505. This oil on panel painting measures 30-1/4 × 21 inches and is currently housed in the Musée du Louvre in Paris. It is widely recognized as the most famous painting in the world and is also known as La Gioconda. The painting is notable for its mysterious smile, which scholars attribute to da Vinci's technique of subtly shadowing the corners of the sitter's mouth and eyes, making her smile enigmatic.
Leonardo da Vinci's Mona Lisa is not only a portrait of what is likely the wife of a Florentine merchant, but it has also become an icon of the Renaissance. The fact that the painting was never delivered to its patron and remained with Leonardo, and later in the possession of Francis I, King of France, adds to its mystique. An important copy located in the Prado Museum in Madrid has provided additional insights into the painting's original appearance.