Question

Which of the following statements applies to the E2 mechanism? Which of the following statements applies to the E2 mechanism? It occurs with inversion of stereochemistry. It occurs with racemization of stereochemistry. The C-H and C-X bonds that break must be anti. Use of a bulky base gives the more highly substituted alkene product. It proceeds through the more stable carbocation intermediate.

Answer 1

The E2 reaction is a type of elimination mechanism where a base removes a proton from a carbon adjacent to one with a leaving group, leading to the creation of a double bond. It requires the bonds to be anti-aligned and uses a bulky base to favor the formation of more highly substituted alkenes, with no intermediates formed.

Step-by-step explanation:

The E2 elimination reaction is a concerted process where a base removes a proton (H) adjacent to a carbon with a leaving group (often denoted as 'X'), resulting in the formation of a double bond. The key characteristics of the E2 mechanism include the requirement for the C-H and C-X bonds to be in an anti-periplanar arrangement, ensuring they are aligned properly for the elimination to occur. Additionally, the use of a bulky base typically leads to the formation of the more highly substituted alkene product, favoring the more stable Zaitsev product. There is also no carbocation intermediate in the E2 mechanism; instead, the reaction proceeds through a single concerted step without intermediates. The E2 mechanism is typically observed with secondary and tertiary substrates where steric hindrance inhibits SN2 reactions.

Answer 2

Question in order:

Which of the following statements applies to the E2 mechanism?

a. It occurs with inversion of stereochemistry.

b. It occurs with racemization of stereochemistry.

c. The C-H and C-X bonds that break must be anti.

d. Use of a bulky base gives the more highly substituted alkene product.

e. It proceeds through the more stable carbocation intermediate

Answer:

option c

Step-by-step explanation:

The reason for the answer is because

Antiperiplanar orientation will lead to E₂ elimination

The attached image shows the structural combination equation