Question

In muscle tissue, the activity of glycogen phosphorylase b is allosterically controlled with

a. ATP acting as a positive effector and glucose 6‑phosphate acting as a negative effector.
b. ATP acting as a positive effector and AMP acting as a negative effector.
c. AMP acting as a positive effector and adenosine acting as a negative effector.
d. AMP acting as a positive effector and ATP acting as a negative effector.

Answer 1

D-AMP acting as a positive effector and ATP acting as a negative effector.

Step-by-step explanation:

AMP stimulates the process of Glycogenolysis; whereas ATP inhibits it. Glucose is first converted into Glucose 6-phosphate which goes through sequential steps and forms Glycogen phosphorylase, this liberates glucose 1-phosphate residues off branched glycogen until 4 glucose units remains on the branch. Further cleavage process occurs and the last residue cleaves off and liberates glucose.

This whole process is stimulated by AMP, Glucagon, Epinephrine and inhibited by ATP, insulin and negative feedback effect of Glucose 6-phosphate