Question

Aminoglycosides ________. Group of answer choices block peptidases that cross-link glycan molecules block folic acid synthesis interfere with elongation of peptidoglycan attach to the 30S ribosomal subunit and disrupt protein synthesis damage cell membranes

Answer 1

Aminoglycosides attach to the 30S ribosomal subunit and disrupt protein synthesis.

Step-by-step explanation:

Mechanism of action of aminoglycosides:

Initially the penetrate the bacterial cell wall, to reach periplasmic space through porin channels.

Further transport across cytoplasmic membrane takes place by active transport by proton pump; an oxygen dependant process.

Aminoglycosides then bind 30S ribosomal subunits and interfare with the initiation complex. Induce misreading of genetic code on mRNA. Also causing the breakup of polysomes into monosomes thus ultimately disruping the protien synthesis.