Question

A lab-reared strain of mice is glucose 6-phosphate-insensitive. How would this affect glycogen synthesis? Select the best answer. Glycogen synthesis would increase because a greater insulin concentration would increase glucose transport. Glycogen synthesis would increase because glycogen synthase would always be active. Glycogen synthesis would decrease because the b form of glycogen synthase could not be allosterically activated. Glycogen synthesis would decrease because the usually inactive b form could not be converted to the always‑active a form. Glycogen synthesis would remain unchanged because other regulatory mechanisms would be unmasked.

Answer 1

The best response is polyose synthesis would decline as a result of the b form of glycogen synthase couldn't be allosterically stimulated. In general, aldohexose six phosphate allosterically stimulates the protein polyose synthase. However as this mice is complex to aldohexose six phosphate, polyose synthase can't be stimulated, and as an effect polyose synthesis would decline.