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What factors contributed to the Cherokees' hardships?

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Answer: Due to the poor sanitation of the internment camps, deadly diseases such as whooping cough, measles and dysentery spread among the Cherokee.

Step-by-step explanation:

User Krasimir
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Answer:

They were removed from their homes.

They walked through terrible weather.

Many of them died from sickness.

User StephenWeiss
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