Question

The amount of enzyme activity in a cell that is homozygous for a mutant allele is 0 units. The amount of enzyme activity in a cell homozygous for the WT allele is 200 units. The amount of enzyme activity in a heterozygote is 0 units. What type of allele is the mutant allele?

a. null/amorphic
b. neomorphic
c. dominant negative
d. hypomorphic
e. hypermorphic

Answer 1

dominant negative

Step-by-step explanation:

Answer 2

The best answer is "C"

Dominant negative

Step-by-step explanation:

Dominant negative represents a class of mutation in which a mutant receptor interferes with the function of the wild-type version of the receptor.

null/amorphic: It is a form of mutation that causes the complete loss of Gene function (protein) by disrupting translation and/or preventing transcription.

Neomorphic: Describes a mutation where altered gene product possesses a completely new molecular function and sometimes pattern of gene expression.

Hypmorphic: describes a mutation that causes a partial loss of gene function usually through reduced (protein, RNA) expression or reduced functional performance.

hypermorphic: describes a mutation that causes an increase in the normal gene function resulting from increased mRNA or protein expression.