Question

Consider these statements regarding the body's inability to convert fat to carbohydrates.

Select each statement that is true.

1. Acetoacetate is a normal, major energy source for the brain, heart muscle, and renal cortex.
2. Acetyl CoA that is produced from the oxidation of fatty acids and enters the citric acid cycle is used in the de novo synthesis of pyruvate.
3. The acetyl CoA that is produced from the oxidation of fatty acids enters the citric acid cycle but does not lead to a net gain of oxaloacetate.
4. The decarboxylation steps of the citric acid cycle prevent the net synthesis of glucose precursors from acetyl CoA in animal tissues.
5. Metabolism of odd-chain fatty acids yields propionyl CoA, which is converted to succinyl CoA and can enter the citric acid cycle.

Answer 1

The body's inability to convert fat to carbohydrates prevents the net synthesis of glucose precursors and does not lead to a net gain of oxaloacetate.

Step-by-step explanation:

The correct statements regarding the body's inability to convert fat to carbohydrates are:

1. Acetyl CoA that is produced from the oxidation of fatty acids and enters the citric acid cycle is used in the de novo synthesis of pyruvate.
2. The acetyl CoA that is produced from the oxidation of fatty acids enters the citric acid cycle but does not lead to a net gain of oxaloacetate.
3. The decarboxylation steps of the citric acid cycle prevent the net synthesis of glucose precursors from acetyl CoA in animal tissues.

Acetoacetate is a normal, major energy source for the brain, heart muscle, and renal cortex, so statement 1 is false. Metabolism of odd-chain fatty acids yields propionyl CoA, which is converted to succinyl CoA and can enter the citric acid cycle, so statement 5 is also false.