Question

Estimate the chronic daily intake of toluene from exposure to a city water supply that contains a toluene concentration equal to the drinking water standard of 1 mg/L. Assume the exposed individual is an adult female who consumes water at the adult rate for 70 years, that she abhors swimming, and that she takes a long (20 minute) bath every day. Assume that the average air concentration during the bath is 1 μg/m3. Assume that the dermal uptake from water (PC) is 9.0 x 10-6m/hr and that direct dermal absorption during bathing is no more than 80% of the available toluene because she is not completely submerged. Use the EPA lifetime exposure of 75 years. Express your answer in mg/kg-day. Which exposure pathway contributes the most to the chronic daily intake?

Answer 1

The chronic daily intake is 0.0328608 mg/kg day

Step-by-step explanation:

The CDI due to ingestion is equal to:

`CDI=(C*IR*ED*EF)/(BW*AT)`

Where

C = concentration = 1 mg/L

IR = 2.3 L/day

ED = risk dying per year = 70 year

EF = number of days per year = 365 days

AT = average tenure time = 75 year

BW = weight of body = 65.4 kg

`CDI=(1*2.3*70*365)/(65.4*365*75) =0.0328mg/kgd`

The ingestion rate is:

IR = 20/60 = 0.333 h/day

The CDI due to dermal contact is equal to:

`CDI_(2) =(1*1.69*9x10^(-6)*0.333*70*365 )/(65.4*365*75)*0.8x10^(3) =5.41x10^(-5) mg/kgd`

The CDI due to inhalation is equal to:

`CDI_(3) =(0.001*0.471*70*365)/(65.4*365*75) =6.7x10^(-6) mg/kgd`

The total is:

CDItotal = 0.0328 + 5.41x10⁻⁵ + 6.7x10⁻⁶ = 0.0328608 mg/kgday