Answer:
Involves mainly B cells and takes place in blood and lymph.
Step-by-step explanation:
Humoral immune response: It is also known as antibody-mediated immunity and defined as the immune response which involves the transformation of B cells into plasma cells that help to obtain and secrete antibodies to a specific antigen.
The humoral immune system deals with antigens that come from pathogens that are freely circulating outside the infected cells. B cells are able to produce antibodies that will bind to the antigens and help them to neutralize, this process takes place in blood and lymph.