Answer:
The statement is true
Step-by-step explanation:
As a fact, I agree that with large sample sizes, even the small differences between the null value and the observed point estimate can be statistically significant.
To put it differently, any differences between the null value and the observed point estimate will be material and/or significant if the samples are large in shape and form.
It's also established that point estimate get more clearer and understandable, and the difference between the mean and the null value can be easily singled out if the sample size is bigger.
Suffix to say, however, while the difference may connote a statistical importance, the practical implication notwithstanding, will be looked and studied on a different set of rules and procedures, beyond the statistical relevance.