The correct answer is Loneliness with depression
When a person feels lonely, he cannot be comfortable, much less feel desired, understood or valued. Such feelings can be confused with depression, which makes the person feel bad in a broader way. However, the symptoms of loneliness can lead to another illness.
Depression is caused by both genetic and biological factors, as well as external factors. Therefore, care must be taken when discussing the triggers of the disease.
Depression is not necessarily aligned with events. Everything may be going very well in the life of a depressed person, but he will continue to show signs of illness until he seeks treatment. Sadness is justified: in general, the person is aware of it and knows what generated the feeling.