Clotting factors
Step-by-step explanation:
Clot enhancers: calcium ions, fibrinogen, thrombin, vitamin K, PF3, tissue factor
- Calcium ions are required for the fibrin clot formation,also helps in the activation of thrombin from prothrombin
- Fibrinogen is the substrate of thrombin and helps in the formation of a normal blood clot at the site of vascular disruption
- Thrombin converts fibrinogen into fibrin which leads to the formation of a fibrin clot;also causes platelet aggregation
- Vitamin K is the fat soluble vitamin which act as coenzyme,the aromatic ring of Vitamin K undergoes in sequential oxidation and reduction during the formation of active prothrombin
- PF3 comes into action whenever there is platelet activation,it is released and participates in thrombin formation
- Tissue factor helps in the initiation of blood coagulation
Clot inhibitors: heparin, coumadin, aspirin
- Heparin is an anticoagulant which prevents the formation of blood clot,used before surgeries to minimize the risk of blood clots
- Coumadin is also known as Warfarin which is a synthetic compound that inhibits the formation of active prothrombin and cause death of organisms due to constitutive bleeding
- Aspirin is a blood clot inhibitor and helps in preventing cardiovascular events in high risk patients
Serum is called blood plasma without fibrinogens and does not play any role in blood clotting(neither as an enhancer nor as an inhibitor)