Question

almodulin is found in smooth muscle cells and performs a similar function to troponin in striated muscle fibers. However, calmodulin not only gets activated by Ca2 but also slows the release of Ca2 from the sarcoplasmic reticulum. How might this difference relate to the different kinds of contractions smooth muscles do in comparison to striated muscles

Answer 1

Calmodulin acts as the main part of the calcium signal transduction pathway in the muscle activity process. It means that it affects the phosphotases and kinases present on the other site by modification of interactions among them. No doubt that troponin as well as calmodulin are members of EFh superfamily yet they differ in the length of their linker region. The reason of their dissimilarity in function is the evolution of calmodulin into binding with more wider range of protein to not just perform in skeletal but a wide range of other physiological events.