Question

Some glucose produced by gluconeogenesis is stored in the body as glycogen. Order the steps of glycogen synthesis. Not all descriptions accurately describe glycogen synthesis; therefore, not all the descriptions will be used.

Answer 1

The correct sequence of the steps is 5,1,2 from the steps given below.

Step-by-step explanation:

As the complete question is not given, the complete question is found online and is attached herewith.

From the steps

1. Pyrophosphates converts PPi and water into Pi.
2. Glycogen synthase adds a glucose unit from UDP-glucose to glycogen, producing a larger glycogen molecule and UDP.
3. Glycogen synthase removes a glucose unit from a glycogen molecule producing a smaller glycogen molecule and UDP.
4. ADP-glucose pyrophosphorylase catalyzes the reaction of glucose-1-phoshate and ATP to ADP-glucose and PPi.
5. UDP-glucose-1-phosphate and and UTP to UDP-glucose and PPi.

The correct order is as below

1. UDP-glucose-1-phosphate and and UTP to UDP-glucose and PPi.
2. Pyrophosphates converts PPi and water into Pi.
3. Glycogen synthase adds a glucose unit from UDP-glucose to glycogen, producing a larger glycogen molecule and UDP.

Answer 2

Glucose cannot be stored directly in the body as it has active groups which makes the glucose very reactive in nature and hence to store as the energy source it must be converted into glycogen. So, by the action of Uridyl Transferase enzyme the glucose is converted to the UDP-glucose which is the precursor of glycogen.

The pyrophosphate which is formed is then hydrolyzed by the action of pyrophosphatase which leads to removal of 2 molecules of .

The enzyme Glycogen synthase adds a glucose unit to the UDP-glucose by the formation of the glycosidic bond to form the polysaccharide glycogen. This reaction further proceeds to form longer chain of glycogen molecule.

From the pyrophosphate group the phosphate group is removed by the action of enzyme and then the glycogen phosphorylase converts the UDP-glucose into glycogen. This Glycogen phosphorylase is activated by the phosphorylation and the phosphate group released by the pyrophosphate group.

Step-by-step explanation:

See attached picture.