Answer:
The correct answer is "valine; lysine".
Step-by-step explanation:
The Sickle-cell disease and hemoglobin C disease are two examples of how a single mutation could have harmful consequences. In Sickle-cell disease, glutamic acid at position 6 in the β-globin is replaced by valine, result of a glutamic acid codon (GAG) being changed into a valine codon (GTG). In hemoglobin C disease, the same glutamic acid is replaced by lysine, which results in the conversion of the normal hemoglobin A (Hb A) into the structural variant of Hemoglobin C (Hb C).