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Mixing a stimulant with a depressant, such as alcohol, is dangerous because:

User Zizoo
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Mixing a stimulant and depressant is extremely dangerous and the body's reaction is often unpredictable. The two types of drug send contradicting messages to the body; as a result the body's function is greatly impaired. ... Mixing stimulants and depressants puts the body under immense pressure.
User Bogdana Zadic
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Answer:

Stimulants and depressants are complete opposites. Stimulants increase function and increase energy and alertness while depressants slow you down to produce tranquilizing side effects. When a person takes both, the body tries to do both at the same time.

User Jackie Honson
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