C. a rise in blood carbon dioxide concentration
Step-by-step explanation:
Negative feed back mechanism refers to the control mechanism in which a product of a particular pathway controls the switch on and switch off of that particular pathway.
Since breathing increases the blood oxygen concentration and lowers carbon dioxide concentration and pH. The sensors that regulate the breathing should respond to oxygen concentration as the carbon dioxide is the by-product of respiration and is responsible for increasing blood pH. Thus increased Carbon dioxide levels in blood is the only factor which will trigger breathing.