Answer: They are always located in the nucleus.
They can undergo a conformational change upon binding of a ligand.
Explanation: Androgen and retinoid receptors are a class of receptors known as intracellular receptors. They are called intracellular receptors because they are usually located within the nucleus of a cell. Androgen and retinoid receptors are receptors to androgen and retinoid hormones respectively. Androgen is a steroid hormone. Androgen and retinoid hormones are water insoluble hormones that can readily pass through the plasma membrane of a cell through simple diffusion in order to its receptor in the nucleus. Intracellular receptors have two binding site: the ligand binding site and DNA binding site. The binding of the hormone to its receptor triggers a change in conformation that enables the binding of a highly specific DNA sequence to the DNA binding site.