Answer:thrombopoietin
Step-by-step explanation:
Thrombopoietin is a protein that is produced in the liver,parenchymal cells and sinusoidal endothelial. The kidney by proximal convoluted tubules,s triated muscle and bone marrow stromal cells also produce some amount.
Thrombopoietin regulates the differentiation of megakaryocytes and platelets.
Thrombopoietin affects some aspects of platelet production this include the self renewal of platelets done by stimulation of the proliferation of megakaryocyte progenitor cells and these support the cells into mature platelet-producing cells.