Question

Make a frameshift mutation use brackets to indicate how the reading frame would be altered by the mutation

ATGCGTCCATGA

Answer 1

Original reading frame=> (ATG)(CGT)(CCA)(TGA)

Altered reading frame => (ATG)(CAC)(GTC)(CAT)(GAG)

Explanation: A frame shift mutation is a type of mutation in which there is addition or deletion of one or more nucleotides in a DNA sequence which results in alterations in the original reading frame of the DNA sequence. In the altered reading frame above two nucleotides were added at positions 4 and 5 thereby changing the subsequent reading frame of the DNA. Frame shift mutation can result in permanent change in DNA sequence during replication and subsequently in altered RNA sequence during transcription and altered amino acid sequence of the final gene product.