Answer:
The best option is C) The disease has made the man insane, but he does not know it.
Step-by-step explanation:
The last option simply puts the two independent clauses together with no punctuation or conjunctions whatsoever. It can, thus, be eliminated. The other options are not appropriate because they change the meaning of the original sentences. The best option is definitely the third one. It uses punctuation - a comma - and a coordinating conjunction - but - to put together two independent sentences. The conjunction "but" indicates contrast, which lies in the fact that the man does not know the disease has made him mad.
Therefore:
(6) The disease has made the man insane. + (7) He does not know it. = The disease has made the man insane, but he does not know it.