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How does the pKa values of an ionizable side chain compare when the amino acid is free versus when it is in a polypeptide chain?
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How does the pKa values of an ionizable side chain compare when the amino acid is free versus when it is in a polypeptide chain?

User Srikanth Josyula
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Answer:

The pKa of the side chain may be lower or higher in a polypeptide chain due to weaker inductive effects and differences in their microenvironments

Step-by-step explanation:

User Gooziec
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