Answer:
The interruption of Lipid A biosynthesis inhibits the growth of the Gram- negative bacteria.
Step-by-step explanation:
- Some bacteria which do not take up Gram staining are called Gram negative bacteria.
- Their cell wall which is the outermost layer is rich in fatty acid and carbohydrates and is called the Lipopolysaccharide or LPS layer.
- Lipid A is an essential component of this LPS layer forming approximately 75% of the layer.
- The LPS layer is essential for providing protection and giving structural stability to the bacterial cell.
- Antibiotics targeting synthesis of Lipid A will make the bacteria deficient in one of its essential structural components, that is, the LPS.
- This will result in the generation of defective progeny bacteria which would not be able to survive, hence causing their death.