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The zona pellucida is formed as the follicle becomes a secondary follicle. True or False

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Answer: The zona pellucida is formed as the follicle becomes a secondary follicle. False

Explanation: As the primary follicle increases in size, adjacent connective tissue organise themselves into a capsule called Theca folliculi. Follicular cells divides actively to produce a stratified layer around the oocyte.

Subsequently, fluid filled spaces appear around the follicular cells which coalesce to form a single large cavity called ANTHRUM. After formation of anthrum, it becomes secondary follicle. The primary follicle becomes surrounded by a covering of amorphous acellular glycoprotein material called Zonal pellucida.

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