Answer:
The answer is "Genomic instability".
Explanation:
The greater mutation rate in the downstream cell genome leads to the genome's heterogeneity, which becomes genetic heterogeneity or molecular disturbance. These changes can include alterations to the nuclear acid chain, genetic rearrangement or aneuploidy.
It's also known as hereditary cancers, that sometimes defined by genetic variations in genes like BRCA1, BRCA2, MSH2, MYH, they lead to genomic disruption in the maintenance genes.