Final answer:
The Lewis and Clark Expedition, aimed at exploring the northern Louisiana Territory, was distinct from Zebulon Pike's Second Expedition, which explored the southern portion and encountered issues with Spanish authorities.
Step-by-step explanation:
Meriwether Lewis and William Clark's Lewis and Clark Expedition aimed to explore the northern parts of the Louisiana Territory and searched for a continuous waterway to the Pacific Ocean, as mandated by President Thomas Jefferson. This mission was guided by Sacagawea, an American Indian woman, and was meant to map the territory and establish trade routes. The expedition spanned from 1804 to 1806 and ultimately failed to find the allusive Northwest Passage but still made significant contributions to the geographical knowledge of the area.
Zebulon Pike's expedition, specifically his Second Expedition, explored the southern parts of the Louisiana Territory and attempted to learn about the Spanish border of the territory. Unlike the journey of Lewis and Clark, Pike's expedition resulted in his arrest before returning to the United States as he ventured into Spanish territory.